India Covid-19 update: Govt may approve vaccine with 50% efficacy, Sputnik V trials soon - Coronavirus News In Hindi - Latest Coronavirus News


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बुधवार, सितंबर 23, 2020

India Covid-19 update: Govt may approve vaccine with 50% efficacy, Sputnik V trials soon

India Covid-19 update: Govt may approve vaccine with 50% efficacy, Sputnik V trials soon

Amid the race to develop a potential vaccine against the novel coronavirus, India's drug regulator today said that it plans to approve Covid-19 vaccines for that can provide immunity to at least 50% of the participants in phase clinical trials, according to a Mint report.

The development comes in the backdrop of both World Health Organisation's and US Food and Drug Administration’s benchmarks that says that a coronavirus vaccine must prove to be at least 50% more effective than a placebo in a large-scale trial to be considered for approval.

Here are the major developments on the manufacturing and clinical trials of Covid-19 vaccines in India:

“To ensure that a widely deployed COVID-19 vaccine is effective, the primary efficacy endpoint estimate for a placebo-controlled efficacy trial should be at least 50%," the Central Drugs Standard Control Organization (CDSCO) said in its draft regulatory guidelines for vaccine development, with special consideration for covid-19 vaccine issued on Monday, reported Mint.

The Indian regulator has also clarified that people who have been infected with the novel coronavirus, SARS-CoV-2, earlier should be allowed to participate in trials as long as they did not have acute Covid-19 or other acute infectious illnesses.

Reddy's Laboratories Ltd, which has recently been roped in for Covid-19 vaccine manufacturing, said that it could begin late-stage clinical trials of Russia's potential coronavirus vaccine in the next few weeks, an executive said.

Indian trials of the Sputnik-V vaccine candidate, being developed by Russia's sovereign wealth fund, will enroll 1,000-2,000 participants and be conducted at multiple government and private hospitals across the country, Deepak Sapra, CEO for API and pharmaceutical services at Dr. Reddy's, told Reuters.

Moreover, the phase-III or the last stage of clinical trial of the Covid-19 vaccine 'Covishield', being developed by Oxford University, and manufactured by the Serum Institute of India (SII), began on Monday at the state-run Sassoon General Hospital in Pune, Maharashtra on Monday, a senior official said.

The Covishield vaccine will be administered as a dose to 150 to 200 volunteers, official had said.

India’s indigenous vaccine developers Bharat Biotech International Ltd. are at the second-phase human trial stage and Zydus Cadila is in the process to receive approvals for conducting third-phase clinical trials.

Meanwhile, SII has started manufacturing Covid-19 vaccine candidate developed by Codagenix Inc, the US biotech said in a statement.

Dubbed as CDX-005, the coronavirus vaccine candidate has completed pre-clinical animal studies. The drug maker aims to initiate phase I clinical trial of its COVID-19 vaccine in the United Kingdom by the end of this year.

A vaccine for the coronavirus will likely be ready by early 2021 but rolling it out safely across India’s 1.3 billion people will be the country’s biggest challenge in fighting its surging epidemic, a leading vaccine scientist told Bloomberg.

Also Read : Coronavirus live updates: India's case tally crosses 54 lakh

Coronavirus live updates: India's Covid-19 recovery rate crosses 81% 

India's Covid-19 caseload went past 56 lakh with 83,347 infections being reported in a day, while over 45 lakh people have recovered from the disease, according to the Union Health Ministry data updated on Wednesday.

Record Recoveries Take India’s Active Cases Below 10 Lakh

Active cases of Covid-19 infection in India fell below the 10-lakh mark after more than a lakh patients recovered in a single day.

The country added a little over 75,000 new cases in a matter of 24 hours -- the lowest in three weeks -- taking the total tally above 55 lakh, according to the Health Ministry’s update as of 8 a.m. on Sept. 22. This includes almost 45 lakh patients who have recovered and more than 88,000 deaths.

Global Update An $18-billion initiative to deploy a vaccine around the world is moving into the next phase, with 156 countries and regions joining the programme. China and the U.S. remain on the sidelines. 

America’s deaths from Covid-19 approached 200,000. U.K. Prime Minister Boris Johnson will announce new restrictions on bars and restaurants. Australia’s Victoria reported a jump of new case as the state moves closer to easing its lockdown in Melbourne. South Korean infections increased by less than 100 for a third day, the first such streak since mid-August. Globally, cases top 31 million, deaths exceed 962,000.

With Daily Jump of 83,347 Cases & 1,085 Deaths, India's Covid-19 Tally Crosses 56 Lakh-mark, Testing Below 10 Lakh

India's Covid-19 case tally crossed the 56-lakh mark today with a spike of 83,347 new cases and 1,085 deaths in last 24 hours.The total case tally stands at 5,646,011 including 9,68,377 active cases. The number of people have been cured, discharged or have migrated is 45,87,614, while the total number of fatalities has risen to 90,020, the Ministry of Health and Family Welfare said. Meanwhile, Prime Minister Boris Johnson told the British people on Tuesday to work from home where possible and ordered restaurants and bars to close early to tackle a fast-spreading second wave of COVID-19, with new restrictions lasting probably six months.

Testing Remains Under 10 Lakh

9,53,683 Covid-19 samples were tested on Tuesday. With this, the total number of samples tested so far stands at 6,62,79,462, the Ministry of Health and Family Welfare said today. The positivity rate stands at to 8.75%.

Also Read : India Count Crosses 52 Lakh With 96,000 New Cases

3,291 Covid-19 Cases, 96 Deaths in Pune, 1,614 Discharged

Pune district reported 3,291 new coronavirus cases in the last 24 hours, taking its COVID-19 count to 2,57,797, while the death toll reached 5,870 after 96 people succumbed to the infection, an official said on Tuesday. A total of 1,614 people were discharged during the day."Of the new cases, 1,364 are in Pune Municipal Corporation limits, which now has 1,34,029 cases. The count in Pimpri Chinchwad increased by 814 to reach 71,641. The number of cases in rural and cantonment areas stands at 52,127," he said.

US President Donald Trump told the United Nations

US President Donald Trump told the United Nations General Assembly on Tuesday that China must be held accountable for having "unleashed" COVID-19 on the world, prompting Beijing to accuse him of "lies" and abusing the UN platform to provoke confrontation. 

China's President Xi Jinping struck a conciliatory tone in his pre-recorded virtual address to the General Assembly, calling for enhanced cooperation over the pandemic and stressing that China had no intention of fighting "either a Cold War or a hot war with any country." "We must hold accountable the nation which unleashed this plague onto the world, China," he said in remarks taped on Monday and delivered remotely to the General Assembly due to the pandemic.

Canada at 'Crossroads' as COVID-19 Cases Surge

COVID-19 infections have surged in Canada and if people do not take stringent precautions, they could balloon to exceed levels seen during the first wave of the pandemic, health officials warned on Monday. "Canada is at a crossroads and individual action to reduce contact rates will decide our path," the Public Health Agency said in a statement.

Cases continue to decline in Chennai, city tally now over 1.57 lakh

Tamil Nadu recorded 5337 positive cases of COVID-19 on Tuesday, bringing the state tally to 5,52,674. Among these, Chennai reported 989 positive cases, bringing the city’s total to 1,57,614.Tamil Nadu recorded 76 deaths on Tuesday, putting the state toll at 8947. 69 of them had succumbed due to comorbidities.As of Tuesday, the number of active COVID-19 cases in Tamil Nadu is 46,350. Till date, 3,33,187 males, 2,19,457 females and 30 transgenders have tested positive for the virus in the state.

According to a bulletin released by the Health and Family Welfare Department of Tamil Nadu, 66,40,058 samples from the state have been sent for testing till date, with 82,928 samples having been sent yesterday.The state discharged 5406 patients following treatment yesterday, putting the total number of recoveries at 4,97,377.

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